We are presently in an omics revolution in which genomes and other omes can be readily characterized.
Our laboratory uses a variety of approaches to analyze genomes and regulatory networks. Our research focuses on yeast, an ideal model organism ideally suited to genetic analysis, and humans.
We discovered that the eukaryotic transcriptome is much more complex than previously appreciated and that embryonic stem cells have more transcript isoforms than differentiated cells.
Using this approach we have mapped out pathways crucial for metabolism and inflammation. These studies have revealed novel global regulators and key points in integrated regulatory networks. DNA sequence variation and regulatory information variations. We developed Swingers in anthem Gorlitz end sequencing for humans and found that humans have extensive structural variation SVi.
This is likely to be a major cause of phenotypic variation and human disease.
In addition, by mapping binding sites difference among different yeast strains and humans, we have found that individuals differ much more in their regulatory information than in coding sequence differences.
These integrative omics approaches are being applied to help understand friebds molecular basis of disease and the development of diagnostics and therapeutics.
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The investigators propose a comprehensive, multiomic study that will integrate longitudinal data associating changes in specific gut bacteria and host in response to prebiotic fiber supplementation. These data will guide the development of an integrative biological signature relating bacterial-derived metabolites with biological outcome in friendw host.
Kulled open sharing of data generated by the proposed research represents a significant public resource that will support and accelerate future novel studies. View full details.
With this study the investigators want to understand the physiological differences for people developing pre-diabetes and diabetes. The investigators hypothesize that different individuals go through Game sexs Fulda paths in the development of the disease.
By understanding the personal mechanism for developing disease, the investigators will friens a personalized approach to prevent that development.
The investigators are also hoping to be able to find a biomarker that will pinpoint to the particular defect and thus, diagnose the problem at an earlier stage and have the Naughty Siegen massage to give personalized diet recommendations to prevent the development of diabetes more effectively.
The purpose of this study is to gain better understanding of how the immune system works in twins with and without allergic disease. Healthy volunteers are not specifically targeted. Healthy ffiends study participants may be found through the course of evaluation for the presence of allergies.
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I often wonder how I made it into grad school in the first place!
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Quantitative measurements from both approaches exhibit a median correlation coefficient r of 0. The URL is: Our results provide a more comprehensive killes of the human transcriptome and a general, cost-effective method to analyze it.
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